Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes.
Identifieur interne : 000123 ( Main/Exploration ); précédent : 000122; suivant : 000124Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes.
Auteurs : Jacob O. Brunkard [États-Unis]Source :
- Developmental cell [ 1878-1551 ] ; 2020.
Abstract
Target of rapamycin (TOR) is a protein kinase that coordinates metabolism with nutrient and energy availability in eukaryotes. TOR and its primary interactors, RAPTOR and LST8, have been remarkably evolutionarily static since they arose in the unicellular last common ancestor of plants, fungi, and animals, but the upstream regulatory mechanisms and downstream effectors of TOR signaling have evolved considerable diversity in these separate lineages. Here, I focus on the roles of exaptation and adaptation in the evolution of novel signaling axes in the TOR network in multicellular eukaryotes, concentrating especially on amino acid sensing, cell-cell signaling, and cell differentiation.
DOI: 10.1016/j.devcel.2020.06.022
PubMed: 32649861
PubMed Central: PMC7346820
Affiliations:
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Brunkard</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Plant Gene Expression Center, U.S. Department of Agriculture Agricultural Research Service, Albany, CA 94710, USA; Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: brunkard@berkeley.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Plant Gene Expression Center, U.S. Department of Agriculture Agricultural Research Service, Albany, CA 94710, USA; Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author></analytic><series><title level="j">Developmental cell</title><idno type="eISSN">1878-1551</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Target of rapamycin (TOR) is a protein kinase that coordinates metabolism with nutrient and energy availability in eukaryotes. TOR and its primary interactors, RAPTOR and LST8, have been remarkably evolutionarily static since they arose in the unicellular last common ancestor of plants, fungi, and animals, but the upstream regulatory mechanisms and downstream effectors of TOR signaling have evolved considerable diversity in these separate lineages. Here, I focus on the roles of exaptation and adaptation in the evolution of novel signaling axes in the TOR network in multicellular eukaryotes, concentrating especially on amino acid sensing, cell-cell signaling, and cell differentiation.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">32649861</PMID><DateRevised><Year>2020</Year><Month>08</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-1551</ISSN><JournalIssue CitedMedium="Internet"><Volume>54</Volume><Issue>2</Issue><PubDate><Year>2020</Year><Month>Jul</Month><Day>20</Day></PubDate></JournalIssue><Title>Developmental cell</Title><ISOAbbreviation>Dev Cell</ISOAbbreviation></Journal><ArticleTitle>Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes.</ArticleTitle><Pagination><MedlinePgn>142-155</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1534-5807(20)30501-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.devcel.2020.06.022</ELocationID><Abstract><AbstractText>Target of rapamycin (TOR) is a protein kinase that coordinates metabolism with nutrient and energy availability in eukaryotes. TOR and its primary interactors, RAPTOR and LST8, have been remarkably evolutionarily static since they arose in the unicellular last common ancestor of plants, fungi, and animals, but the upstream regulatory mechanisms and downstream effectors of TOR signaling have evolved considerable diversity in these separate lineages. Here, I focus on the roles of exaptation and adaptation in the evolution of novel signaling axes in the TOR network in multicellular eukaryotes, concentrating especially on amino acid sensing, cell-cell signaling, and cell differentiation.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brunkard</LastName><ForeName>Jacob O</ForeName><Initials>JO</Initials><AffiliationInfo><Affiliation>Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Plant Gene Expression Center, U.S. Department of Agriculture Agricultural Research Service, Albany, CA 94710, USA; Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA. 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